Microfluidic fabrication of hydrogel microparticles with MOF-armoured multi-enzymes for cascade biocatalytic reactions
نویسندگان
چکیده
Uniform hydrogel microparticles with ZIF-8 nanoparticles for molecular co-confinement of cascade enzymes are developed by microfluidics to achieve enhanced stability and reusability under harsh conditions.
منابع مشابه
Microfluidic fabrication of hydrogel microparticles containing functionalized viral nanotemplates.
We demonstrate rapid microfluidic fabrication of hybrid microparticles composed of functionalized viral nanotemplates directly embedded in polymeric hydrogels. Specifically, genetically modified tobacco mosaic virus (TMV) templates were covalently labeled with fluorescent markers or metalized with palladium (Pd) nanoparticles (Pd-TMV) and then suspended in a poly(ethylene glycol)-based solution...
متن کاملThe hydrogel template method for fabrication of homogeneous nano/microparticles.
Nano/microparticles have been used widely in drug delivery applications. The majority of the particles are prepared by the conventional emulsion methods, which tend to result in particles with heterogeneous size distribution with sub-optimal drug loading and release properties. Recently, microfabrication methods have been used to make nano/microparticles with a monodisperse size distribution. T...
متن کاملDroplet based microfluidic fabrication of designer microparticles for encapsulation applications.
Developing carriers of active ingredients with pre-determined release kinetics is a main challenge in the field of controlled release. In this work, we fabricate designer microparticles as carriers of active ingredients using droplet microfluidics. We show that monodisperse droplet templates do not necessarily produce monodisperse particles. Magnetic stirring, which is often used to enhance the...
متن کاملMicrofluidic-based synthesis of non-spherical magnetic hydrogel microparticles.
Spherical and non-spherical magnetic hydrogel particles were synthesized in a microfluidic device containing an embedded UV light reflector. Monodisperse magnetic emulsion droplets were generated in a T-junction and allowed to relax into spheres, disks, and plugs in confining microchannel geometries. Particle morphology was locked-in via UV-initiated photopolymerization. The role of the reflect...
متن کاملMicrofluidic multi-input reactor for biocatalytic synthesis using transketolase☆
Biocatalytic synthesis in continuous-flow microreactors is of increasing interest for the production of specialty chemicals. However, the yield of production achievable in these reactors can be limited by the adverse effects of high substrate concentration on the biocatalyst, including inhibition and denaturation. Fed-batch reactors have been developed in order to overcome this problem, but no ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reaction Chemistry and Engineering
سال: 2022
ISSN: ['2058-9883']
DOI: https://doi.org/10.1039/d1re00257k